The French head coach is set to call time on his Gunners reign at end of the current campaign.
Wenger’s side are in sixth place in the Premier League table and look likely to finish outside the top four for the second successive season.
The Gunners can still qualify for the Champions League if Arsenal manage to beat La Liga giants Atletico Madrid in the Europa League semi-finals.
The north London side will travel to the Spanish capital next week to take on los Rojiblancos following a 1-1 draw at the Emirates Stadium on Thursday.
Wenger has won three Premier League titles and eight FA Cups during a decorated 22-season spell at the north London club.
Speaking to ESPN ahead of Wenger’s final clash against Mourinho as Arsenal manager, the Manchester United boss said:
“It’s symbolic because it’s the last one,” Mourinho told ESPN.
“There will never be another Wenger. The football world does not permit the existence of another Wenger or [Sir Alex] Ferguson.
“The social media world doesn’t let it happen, so it’s over. And that’s a shame because a professional with stability and years in a club can aggregate not only in the team but also fundamentally, which is more important. And it’s sad that he’s the last one.”
Arsenal haven’t won the Premier League title since 2003-04 when club legends such as Thierry Henry, Robert Pires and Patrick Vieira led the Gunners to title glory.
Indeed, Mourinho hadn’t even moved to English football when Wenger last got his hands on the Premier League trophy.
The Manchester United boss has won the title three times with Chelsea FC.
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