The Reds warmed up for the bitter clash with a resounding 3-0 win against Premier League leaders Manchester City in the first leg of their Champions League quarter-final clash on Wednesday night.
Liverpool FC were 3-0 up at half-time thanks to goals from Mohamed Salah, Alex Oxlade-Chamberlain and Mane before the Egypt international was forced off with an injury problem in the second half.
Salah is a doubt for the Merseyside derby as a result and Jurgen Klopp will surely be loathe to risk his top goal-scorer ahead of the second leg at The Etihad.
Mane scored in victories over Everton home and away in the 2016-17 season, although the African forward failed to get on the score sheet in this campaign’s two previous meetings.
Former Southampton star Le Tissier believes Liverpool FC will beat Everton thanks to Mane’s brilliance at Goodison Park on Saturday afternoon.
“I’m only going for such a low score because of the amount of effort put in at Man City,” Le Tissier told Sky Sports.
“Klopp will rest a few and I wouldn’t expect Salah to play, but I still think they’ll be too strong and I’m backing a Mane brace in their main man’s absence.
“I know it’s a derby but there’s not much for Everton to play for at this stage of the season and they’ve hardly shown the sort of fight required so far.”
Mane moved to Liverpool FC in a £30m deal from Le Tissier’s former club Southampton in the 2016 summer transfer window.
The Reds are in third place in the Premier League table but a mere two points adrift of Manchester United.
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