The Reds will make the short trip across Stanley Park to take on the Toffees in the Premier League’s early kick-off on Saturday.
Liverpool FC were 3-0 winners against Premier League leaders Manchester City in the first leg of their Champions League quarter-final on Wednesday night.
Goals from Mohamed Salah, Alex Oxlade-Chamberlain and Roberto Firmino secured a comfortable win to edge one step closer to the Champions League last four.
Salah was taken off in the second half of the European clash due to an injury concern, with the second leg set to take place at The Etihad on Tuesday night.
Jurgen Klopp could be tempted to play a second string team for the Merseyside derby ahead of the return leg at Manchester City.
Former Liverpool FC defender Thompson admitted that he would settle for a point ahead of one of the biggest games in the club’s recent history.
“Emotionally and physically, Wednesday night would have taken it out of the Liverpool players. Mohamed Salah won’t be risked on Saturday, Sadio Mane took a knock, but Jordan Henderson will certainly be involved after picking up that booking which rules him out of the second leg,” Thompson told Sky Sports.
“I’d hope Klopp will still go as strong as he can as Everton will be up for this. I don’t think they put in one tackle against Manchester City last week but you can bet your bottom dollar they will be fired up for it.
“I think if we can take the sting out of this game with an early goal then we’ll get a positive result, because if they get frustrated another time then I can see their fans boiling over, so the first goal is going to be crucial but Jurgen Klopp’s selection concerns me.”
Liverpool FC are in third place in the Premier League table and 10 points ahead of Chelsea FC in the race to secure a Champions League spot.
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