The Reds are fresh from an incredible 3-0 win over Premier League leaders Manchester City in the first leg of their Champions League quarter-final on Wednesday night.
Goals from Mohamed Salah, Alex Oxlade-Chamberlain and Roberto Firmino secured a resounding win for the home side.
Salah was forced off in the second half due to an injury concern, while Klopp will be desperate to keep his key individuals healthy ahead of the return leg against Manchester City at The Etihad on Tuesday.
Liverpool FC are in third place in the Premier League table and 10 points ahead of defending Premier League champions Chelsea FC, who are in fifth spot.
Former Arsenal defender Keown believes Klopp should ring the changes for Liverpool FC’s clash against Everton in Saturday’s Merseyside derby at Goodison Park.
“He will need to sacrifice some players for the good of his season,” Keown told the Daily Mail.
“I’ve been impressed with how Klopp has rotated Liverpool’s squad this season.
“I think he struggled to rotate his squad properly during his first season in charge, when he had to balance Europa League with the Premier League, but they looked better last season without European commitments and even fresher now.
“He bought well in January, which has helped combat fatigue, but they still have the likes of Joel Matip, Mo Salah and Adam Lallana suffering from muscular injuries.
“His players will have bounced out of bed this morning after the euphoria of last night, so Klopp has to manage them carefully. He will be desperate to keep the rest of his squad fit, so I wouldn’t be surprised to see changes. He just has to get the balance right.”
Liverpool FC are looking to win the Champions League for the first time since 2005 when the Reds came from 3-0 down to beat AC Milan on penalties in Istanbul.
The Reds lost 2-1 to AC Milan in their last Champions League final appearance in Athens in 2007.
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