The Reds booked their place in the last-eight draw thanks to a 5-0 aggregate win against FC Porto in the Champions League round of 16 last month.
Sadio Mane scored a hat-trick in Portugal to put the Merseyside outfit in control of the tie against the 2004 champions.
Liverpool FC are the only Premier League team to have beaten Pep Guardiola’s side in the English top flight this term following a dramatic 4-3 victory over Manchester City at Anfield back in February.
Manchester City, though, were 5-0 winners at the Etihad Stadium in the Premier League back in September, while the Citizens are 18 points ahead of Liverpool FC in the top-flight table.
Former Reds striker Kuyt is optimistic that Liverpool FC can secure a positive result against the Citizens in the first leg of their Champions League quarter-finals on Wednesday night.
“Because it’s football it’s difficult to say. Everyone always tries to predict football but nobody does really!” Kuyt told Liverpool FC’s website.
“That’s why football is such a great game, nobody can predict it. Always people say, ‘it’s better to play away first’, but if you get beat 3-0 in the first game then you don’t even have to bother playing the home game anymore!
“For example, if we beat City in the first game with maybe one or two goals difference, then the mental game at City will be totally different.
“You just have to give everything in those kinds of games. I think it’s great to play the first game at Anfield, to show who we are in the same style we did in the league game. Then we will have a great chance to win at Anfield, and we will see [what happens] when we go to the City stadium without any fear.”
Liverpool FC finished in fourth place in the Premier League table last season to secure a return to the Champions League.
Manchester City are looking to get their hands on the European Cup for the first time.
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