The Red Devils will take on a Baggies side that have failed to record a win in their last 15 games on the road.
West Brom axed Alan Pardew earlier this month after the Baggies sacked Tony Pulis earlier in the 2017-18 season due to his dour management style.
Manchester United have won their last five Premier League games to move four points clear of third-placed Liverpool FC in the race to finish as runners up behind Manchester City.
The Red Devils are looking to secure their best finish since Sir Alex Ferguson led Manchester United to the Premier League crown in 2013.
The Baggies have lost five of their last six Premier League games in what has been a poor season for West Brom.
Former Liverpool FC striker Owen is backing Manchester United to ease to a low-scoring win against the Baggies at Old Trafford.
“United have kept a league-high 16 clean sheets in the league so far this season and with a trip to Bournemouth to come on Wednesday I expect to see a no-frills success from Jose Mourinho’s side whose confidence must be sky-high after their Etihad derby win,” Owen told BetVictor.
“The Baggies have not won in their last 15 away league games while United have won their last five league games. This looks a banker home win.”
Manchester United will take on Tottenham in the FA Cup semi-finals at Wembley later this month.
The Red Devils signed Chile international Alexis Sanchez in a swap deal from Arsenal in the January transfer window.
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