Spurs will travel to Italy fresh from a disappointing run in the Premier League following successive home losses to undermine their title challenge.
Tottenham lost 2-1 to Watford at Vicarage Road ahead of the international break before a 2-1 defeat by title rivals Liverpool FC at Wembley on Saturday.
The north London side are six points adrift of current Premier League leaders Chelsea FC and Liverpool FC following back-to-back Premier League losses.
Pochettino’s side will make the trip to Inter Milan on Tuesday as Tottenham look to bounce back from a difficult spell in the English top flight.
Inter Milan have also made a difficult start to the Serie A campaign following Sassuolo and Parma Cacio 1913 to leave the San Siro side in 14th spot.
Former Liverpool FC striker Owen is tipping Tottenham to secure a score draw at Inter Milan to make an unbeaten start to their Champions League group stage campaign.
“The clubs have shared the four previous European meetings between the sides with all four games being won by the home side,” Owen told BetVictor.
“Those four games have averaged almost 5 goals per game and I expect to see goals in the San Siro again midweek.
“Despite a poor performance from Mauricio Pochettino’s side at Wembley against Liverpool on Saturday I expect Spurs to bounce back in Milan and pick up a point.
“Inter are in the group stages for the first time in seven years and lost at home to Parma in Serie A at the weekend.”
Tottenham reached the Champions League round of 16 before a 3-2 loss to Serie A champions Juventus.
Spurs failed to make any signings in the summer transfer window.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news