The Red Devils will be looking to make a much-needed return to winning ways after a tough week for Mourinho and his Manchester United squad.
Manchester United played out a 1-1 draw with promoted side Wolverhampton Wanderers last weekend to lose ground on Premier League leaders Liverpool FC.
The Red Devils limped out of the League Cup following a surprise 8-7 loss on penalties to Championship side Derby County.
Manchester United have already lost three games in all competitions in the current campaign to heap pressure on Mourinho.
The Red Devils will make the long trip to West Ham in their next Premier League game on Saturday afternoon.
However, Manchester United will face a West Ham side that beaten Everton and secure a point against Chelsea FC in their last two outings.
Speaking at his pre-match media conference at Carrington ahead of the Premier League clash, Mourinho said:
“Only Marcos Rojo is still out. And obviously Sergio Romero now with a one-match suspension. Apart from that, in a 26-player squad, everybody is available.”
Manchester United finished in second spot in the Premier League table but ended up 19 points adrift of champions Manchester City.
The Red Devils are eight points adrift of leaders Liverpool FC.
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