The Portugal international will be part of Juve’s travelling party for their clash against the Premier League’s most decorated club.
Manchester United are two points behind the Serie A champions in their group after Juventus beat Valencia and Young Boys in their opening two games.
Ronaldo was sent off in Juve’s opening day win at Valencia but his ban was reduced to one game to ensure the three-time Premier League winner will be able to feature in Manchester.
The Red Devils were 3-0 winners against the Swiss side to make a winning start to their European campaign before a 0-0 draw with Valencia at Old Trafford last time out.
Manchester United produced an impressive performance at Stamford Bridge at the weekend after Anthony Martial’s scored twice in the second half to cancel out Antonio Rudiger’s opener.
Jose Mourinho’s men were denied a massive three points when Ross Barkley netted an injury-time winner and the coaching staff’s celebration sparked an angry reaction from the Manchester United bench.
Former Liverpool FC striker Owen, who won the Premier League title with the Old Trafford side in 2011, is backing Manchester United to draw for the third time in their last four games on Tuesday night.
“These great clubs have met 12 previous times in European competition with both teams having five previous wins to their name,” Owen told BetVictor.
“I think the points will be shared at Old Trafford in what promises to be a cracker.
“United have not conceded in the Champions League so far this season, but Cristiano Ronaldo has scored in both his previous appearances against United in the competition and Jose Mourinho’s side will do well to keep the Italians at arm’s length at Old Trafford.
“Paul Pogba is also playing against his former club – for the first time – and he has had a hand in all three United goals in the CL so far this term.”
Manchester United are set to meet Juventus for the first time in 15 years after the pair had a huge rivalry in the 1990s under Sir Alex Ferguson.
The Red Devils lost three of their four meetings with the Serie A side in the Champions League group stage in 1995/96 and 1996/97.
However, a Roy Keane-inspired Manchester United were 3-2 winners in Turin to secure a sensational comeback after a 1-1 draw at Old Trafford in the first leg of their semi-final.
Of course, their 5-4 aggregate win booked their place in the Champions League final in 1999, which Manchester United won 2-1 against Bayern Munich at Camp Nou.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news