Tottenham head into the European clash looking to pick up their first points of the season in the Champions League after having slumped to a 2-1 defeat by Inter Milan in their opener last month.
Spurs were 2-0 winners at Huddersfield Town at the weekend as Mauricio Pochettino’s men moved up into fourth place in the Premier League table.
The north London side are currently just four points behind leaders Manchester City as the Premier League title race begins to take shape this season.
Spurs now have the small matter of welcoming FC Barcelona to Wembley on Wednesday night as they look to try and get some points on the board in their group.
And Nicholas believes that the Spanish giants are likely to have just too much for the Lilywhites this week.
Speaking to Sky Sports, Nicholas said: “Tottenham got their needed win at the weekend against Huddersfield and Harry Kane is scoring again, so they go into this in good mood. Barcelona have improved defensively despite still stuttering and the manager making too many changes.
“However, Lionel Messi is fresh, having played only 20 minutes at the weekend. Barca will be patient and try and control possession, but that’s what Spurs will want to do too, so whoever can do that will be key. I expect it to be an open game and Spurs to give the Spanish giants a hard time.
“It will come down to that extra bit of quality and that’s what Barcelona have. The stage is set for Messi to do something magical.”
Tottenham are aiming to be one of the main contenders for the Premier League this season after they finished in third place last term and without a trophy.
They will host Cardiff City in their next Premier League game on Saturday afternoon.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news