The French midfielder missed the game through injury as Mourinho brought Marouane Fellaini into midfield for the Red Devils at The Etihad.
Manchester United ended up losing the game as goals from David Silva, Sergio Aguero and Ilkay Gundogan wrapped up the three points for Pep Guardiola’s men and kept their place at the top of the table.
The Red Devils had managed to halve the deficit in the second half when Anthony Martial dispatched his penalty to make it 2-1 – but they were unable to find a second goal.
Pogba watched on from the stands during the defeat and Mourinho openly admitted that the Red Devils did suffer from his absence.
Speaking at his post-match news conference about Pogba’s absence, Mourinho said: “It is not for me, after a defeat, to speak about a player who was not here [Pogba].
“Of course, we missed him and one of the things that breaks a little bit, a lot of our plan, is the fact Fellaini had to start.
“He is not in the conditions to play 90 minutes. He was phenomenal in his effort but not in the conditions.
“Normally, adding Fellaini to this late part of the game, you have the image of him fresh coming on at 2-1 with 25 minutes to go, it is an important thing for us.”
The loss left Manchester United down in eighth place in the Premier League table and 12 points behind leaders Manchester City.
The Red Devils will return to Premier League action after the international break when they take on Crystal Palace at Old Trafford on Saturday 24 November as they look to try and return to winning ways.
The next big game in the to flight for the Red Devils will be when they take on Arsenal at Old Trafford on Wednesday 5 December 2018.
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