The Red Devils made a return to winning ways on Tuesday night thanks to Manchester United’s 1-0 victory over Swiss side Young Boys.
Marouane Fellaini was the unlikely hero after the Belgian midfielder scored a 91st-minute winner to seal their place in the Champions League last 16.
Manchester United will return to domestic action this weekend with a long trip to Southampton at St Mary’s last weekend after a two-games winless run.
The 20-time English champions lost 3-1 to leaders Manchester City at The Etihad before Manchester United were held to a goalless draw with Crystal Palace.
The Red Devils have only managed to win six of their opening 13 games in the Premier League to leave Manchester United eight points adrift of fourth-placed Chelsea FC.
Manchester United traditionally have a mixed record at Southampton in the Premier League era, with the Red Devils winning 12 of their 41 games against the Saints.
Former Liverpool FC striker Owen believes Manchester United will play out a low-scoring game against Southampton on Saturday afternoon.
“With too many stars off colour the club find themselves back down in seventh place. They face a trip to the South Coast to take on Southampton who are also desperate for a win with former United great Mark Hughes now favourite to be the next manager to leave,” Owen told BetVictor.
“Saints were out of luck at Leicester Tuesday when VAR chalked off a potential winning goal in the Cup and they look a side needing a lucky break from somewhere.
“United were toothless against Palace at Old Trafford last week whilst the Saints are only off the bottom on goal difference and were once again leaking goals when beaten 3-2 at fellow strugglers Fulham.
Owen added: “With both teams in poor form it’s the visitors who make more appeal at the prices with United only a shade of odds on at 9/10. It won’t be pretty and is sure to be low scoring.”
Manchester United have lost three times on the road in the Premier League this season, suffering defeats by Brighton, Manchester City and West Ham United.
The Red Devils were 1-0 winners at Southampton last season before a goalless stalemate at Old Trafford in the return fixture.
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