The Red Devils will be eager to make a return to winning ways at Old Trafford after losing ground on the top four.
Manchester United suffered a 3-1 loss to defending champions Manchester City at The Etihad last month to bring to a halt their building momentum.
The 20-time English champions were held to a goalless draw with Crystal Palace at Old Trafford last weekend after Jose Mourinho’s side were unable to break down the Eagles.
The Red Devils booked their place in the Champions League knockout stage in mid-week thanks to Manchester United’s 1-0 victory over Swiss side Young Boys.
Marouane Fellaini scored a 91st-minute winner to build some confidence in the Manchester United team ahead of their trip to Southampton.
The Saints are winless in their last nine games stretching back to early September, leaving Mark Hughes’ side in the bottom three.
Former Liverpool FC defender Lawrenson believes Manchester United will secure a vital win in their pursuit of a top-four finish at Southampton on Saturday evening.
“Nothing seems to be working for Southampton at the moment and, although Manchester United are hardly firing on all cylinders, I still expect them to be too strong for Saints,” Lawrenson told BBC Sport.
“I just look at this game and cannot see Mark Hughes’ side causing United enough problems to beat them.
“This United side has got issues of their own in attack, as we have seen in their past two games against Crystal Palace and Young Boys, but I would back them to find a way to win on Saturday.”
Manchester United have conceded 21 times in 13 games in the Premier League this season to raise questions about their defence.
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