The Blues are in fourth place in the Premier League table and five points ahead of Arsenal in the race to secure the final Champions League spot.
Chelsea FC have won their last two Premier League games thanks to victories over Crystal Palace and Watford to bounce back from a 1-0 loss to Leicester.
Sarri’s side have collected 21 points from 10 home games in the Premier League this season, only losing to Leicester City at Stamford Bridge.
Southampton, on the other hand, have collected seven points from 10 fixtures on the road in the Premier League.
The Saints suffered a 3-0 loss to Chelsea FC in their meeting earlier this season after goals from Eden Hazard, Alvaro Morata and Ross Barkley.
Chelsea FC have won their last six games against Southampton in all competitions.
Former Liverpool FC striker Owen is backing Chelsea FC to edge to victory over Southampton at Stamford Bridge on Wednesday evening.
“Chelsea were narrow but convincing winners at Selhurst Park on Sunday and I feel they will put behind their loss to Leicester in their last home game,” Owen told BetVictor.
“The Saints made six changes to the side beaten at home by West Ham when Manchester City were the visitors and I was slightly surprised to see the inform Nathan Redmond left on the bench until the second half.
“By that time the Saints were 3-1 down – I expect the points to stay in the capital.”
Chelsea FC have scored seven times in their last three Premier League meetings against Southampton at Stamford Bridge.
The Blues are five points ahead of Arsenal in the race to secure fourth spot in the table.
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