Pep Guardiola’s side are looking to reach the Champions League quarter-finals for the second successive season under the former FC Barcelona manager.
The Citizens saw their European run come to an end last season after a 5-2 defeat by Liverpool FC in the last eight.
Manchester City were 2-0 winners against Schalke 04 in their last meeting in the Uefa Europa League in 2008.
Goals from Benjani and Stephen Ireland sealed a narrow win for the Citizens under Mark Hughes.
Vincent Kompany is the only surviving member of that Manchester City team as the Belgian defender looks to captain the Eastlands outfit to their first Champions League title.
Former Liverpool FC striker Owen is backing Manchester City to beat Schalke 04 in the first leg of their last-16 clash at Arena AufSchalke.
“Schalke are unbeaten in their last nine home European games, but they have been knocked out at this stage of the Champions League on their last three appearances in the competition and I can’t see past a City win,” Owen told BetVictor.
“The Bundesliga outfit only scored six times in the Group stages, although they did keep four clean sheets, but they will do well to keep this rampant City side at arm’s length.”
Schalke’s last three Champions League campaigns have all ended in the round of 16.
The German club reached the semi-finals in 2010/11 when they lost to Manchester City’s bitter rivals Manchester United over two legs.
The Bundesliga side haven’t been past the round of 16 in three attempts since that loss to the Premier League club.
Manchester City have been in the Champions League round of 16 since 2013-14, but they have won only two of those five previous ties.
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