The defending Premier League champions will make the short trip across the city to take on Ole Gunnar Solskjaer’s side in what could be a pivotal game in both the title and top-four race with four games remaining.
Manchester City came through a tough test against third-placed Tottenham Hotspur at the weekend thanks to Phil Foden’s fourth-minute goal for the home side.
The Red Devils had the chance to move level on points with Tottenham after their loss at The Etihad but Manchester United slumped to a 4-0 defeat at Everton.
Manchester United have now lost their last five away games in all competitions – and their loss at Goodison Park was their heaviest defeat since October 2016.
But the 20-time English champions will have pride to play for as Solskjaer’s side look to damage Manchester City’s title ambitions.
Former Manchester United striker Owen refused to pick a winner of the derby.
“City have only lost one of their last seven league visits to Old Trafford but United badly need to bounce back after their abject display at Goodison on Sunday,” Owen told BetVictor.
“All at the club will be hurting after their 4-0 defeat at Everton but they have the ideal opportunity on Wednesday to put the record straight – they certainly cannot play as badly again.
“City must do without Kevin de Bruyne – injured against Spurs at the weekend – which is a huge loss for the champions, but I expect to see opportunities and goals at both ends. United are unbeaten in their last 14 home league games but have kept just the two clean sheets in the league this season.
“This Manchester derby is a massive game for both teams and one which, I feel, could be pivotal in the destiny of the 2018/19 Premier League title.”
Manchester City are in second place in the Premier League table and two points behind Liverpool FC having played one game less than Jurgen Klopp’s side.
The Citizens can still win the domestic treble this season.
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