The Reds suffered a 3-0 loss to FC Barcelona in the first leg of their Champions League semi-final at Camp Nou last week.
Liverpool FC had more attempts on goal and finished with 52 per cent of the possession but goals from Luis Suarez and Lionel Messi sealed a home win for FC Barcelona.
Jurgen Klopp’s side will be hoping another special European night at Anfield could help Liverpool FC’s chances of completing a memorable comeback.
While FC Barcelona are in a seemingly commanding position, the Spanish side exited the competition last season after squandering a 3-0 first-leg lead against AS Roma in the quarter-final.
Former Liverpool FC striker Owen is backing FC Barcelona to get on the score-sheet at Anfield and leave the Merseyside outfit with a slim chance of reaching the Champions League final.
“History is against Liverpool overturning their 3-0 deficit from the 1st leg in the Nou Camp,” Owen told BetVictor.
“The Reds would become just the third side in the history of the European Cup/Champions League to come from three goals down in the first leg of a semi-final to qualify for the final and the first since Barcelona themselves in 1986.
“That said, Barca held a three-goal lead (4-1) against Roma in last season’s quarter-final before going out on away goals having lost the second leg 3-0 in Italy.
“That must give Jurgen Klopp, his resilient, history-making side and all Reds supporters cause for optimism ahead of what promises to be another wonderful Anfield occasion.
“I naturally hoped Mo Salah would be fit for the visit of Barcelona. The Egyptian has been outstanding in recent weeks and he gave Gerard Pique and co a torrid time in the Nou Camp despite the Reds drawing a rare blank. Had Liverpool scored in Spain I would have been optimistic of the Reds turning the tie around.
“As it is, I expect to see the Reds win at Anfield, but I fear a Barca goal will change the landscape of the tie and it is likely that the Reds will, at some stage, have to throw caution to the wind.”
Liverpool FC lost 3-1 to Real Madrid in the Champions League final last term after Loris Karius endured 90 minutes to forget in Kiev.
The Reds are sitting in second place in the Premier League table and a point adrift of Manchester City with one game to play.
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