The Reds were 3-0 winners against Burnley at Turf Moor last time out to finish at the top of the Premier League table after four rounds of fixtures.
Liverpool FC have beaten Norwich City, Southampton, Arsenal and Burnley to build a two-point lead over defending champions Manchester City.
The Champions League title holders will take on a Newcastle side who are still trying to find their feet under Steve Bruce.
The Magpies played out a 1-1 draw with Watford last time out – and their only victory so far came against Tottenham Hotspur.
Former Liverpool FC striker Owen is backing the Reds to ease to a comfortable 2-0 win over Newcastle in the early kick-off.
“Kevin Keegan was Newcastle boss the last time United won at Anfield in the Premier League – April 1994 – and it is hard to make a case for them against this current Liverpool side who have won their last 13 league games – a record for the club.,” Owen told BetVictor.
“Yes, the Magpies did win at the new Tottenham Hotspur Stadium in their last league game on the road but, as good as Spurs are, they are not Liverpool and I expect the Reds to make it 14 successive league wins.
“Do note they have scored at least twice on each occasion in this record-breaking sequence.”
The Merseyside outfit are looking to win the Premier League title for the first time after Jurgen Klopp’s men ended up a point adrift of top spot last term.
Liverpool FC finished with a record 97 points after losing just one game in the Premier League title race but the Reds paid the price for too many draws.
The Reds will start the defence of their Champions League crown with a clash against Napoli on Tuesday.
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