The west London side head into the game fresh from their 1-0 victory over Newcastle United in the Premier League on Saturday afternoon as the Blues continued their improved form under Frank Lampard.
Chelsea FC will now be looking to take their domestic form onto the European stage as they look to beat Ajax on Wednesday night.
The Blues lost their Champions League opener to Valencia last month but they bounced back with a victory against Lille last time out.
Despite their recent upturn in form, former Arsenal star Nicholas is tipping Ajax to cause Chelsea FC problems and hold them to a draw.
Writing in his column for Sky Sports, Nicholas said: “These are always the same.
“Three players left Ajax, but they have real talent and are going well in the Eredivisie. Everybody is raving about Chelsea’s youngsters too – at the weekend I thought they would struggle against Newcastle.
“People are quite rightly complimenting Tammy Abraham, Mason Mount and Callum Hudson-Odoi.
“At this age, they will go through a quiet spell, but does Frank Lampard keep them in during this or take them out for the Champions League?
“Ajax will look to have a lot of possession whereas Chelsea normally get that. They are a good counter-attack team but Ajax will cause them problems.”
Chelsea FC have won their last three games in the Premier League and they will be hoping to make it four in a row when they travel to Burnley in the Premier League on Saturday night.
The Blues are aiming to maintain their spot in the top four after they finished third under Maurizio Sarri last term.
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