The Gunners head into the game looking to return to winning ways after the disappointment of their 2-0 loss to Leicester City last time out.
Arsenal have only won four of their opening 12 games in the Premier League this season and that poor run of form has heaped pressure on Unai Emery.
The north London side are down in sixth place in the table and already eight points behind fourth-placed Manchester City heading into this weekend’s round of games.
Arsenal have only managed won Premier League win in their last five top-flight outings and they will be hoping to claim the three points when they host 19th-placed Southampton on Saturday.
Former Arsenal star Nicholas is not expecting the Gunners to have any problems when they host the Saints at The Emirates this weekend.
Writing in his column for Sky Sports, Nicholas said: “This will have been a banker in the past. Southampton normally don’t get anything at the Emirates in the Premier League.
“By now, the Arsenal players will have returned and Unai Emery will have had some words to say to them. These are two managers under scrutiny.
“Southampton are getting credit after their response to the 9-0 drubbing but they keep getting beat. The goalkeeper and the back three are still vulnerable.
“Alexandre Lacazette was not on international duty and Pierre-Emerick Aubameyang has been a bit quiet recently, so it is time for Arsenal to get back to winning ways. They are sixth in table and have been awful.
“Chelsea are going to Manchester City, which could bring back a little belief once more that the top four is achievable. These are the games you are expected to win and Arsenal will win.”
Arsenal are aiming to try and break back into the top four this season after they finished fifth and without a trophy in Emery’s first campaign in charge last season.
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