The Reds moved nine points clear of the defending Premier League champions thanks to a 3-1 win against Pep Guardiola’s side at Anfield on Sunday afternoon.
Goals from Fabinho, Mohamed Salah and Sadio Mane secured three points for the home side at Anfield before Manchester City winger Bernardo Silva netted a consolation goal.
Liverpool FC’s closest title rivals are now Leicester City and Chelsea FC, who trail Jurgen Klopp’s men by eight points after their respective victories over Arsenal and Crystal Palace on Saturday.
The Reds have a nine-point advantage over Manchester City ahead of the Eastland outfit’s next Premier League fixture against third-placed Chelsea FC on Saturday 23 November.
The Citizens have also got to play Manchester United in the derby at Old Trafford on 7 December before the Citizens take on Arsenal at The Emirates a week later.
Former Arsenal manager Wenger believes Guardiola’s side will struggle to overhaul Liverpool FC in the Premier League title race.
“First of all, to lose a big game is terrible,” Wenger told beIN Sports.
“You saw the reactions from both of the managers tonight. You can see the pressure they are under and how much a game like that means to both of them.
“Pep will go home and be absolutely devastated, more than you think. If you think a quantity, add 100% and you might get close to that.
“Overall, nine points is too big a difference for Man City after 12 games.”
The Reds have already beaten Arsenal, Chelsea FC, Leicester City, Manchester City and Tottenham Hotspur in the first round of fixtures this season.
Only Manchester United have managed to prevent Liverpool FC from winning after a 1-1 draw at Old Trafford.
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