The Reds will welcome the Serie A side to Merseyside in their penultimate group-stage fixture.
Liverpool FC are sitting at the top of Group E and a point ahead of Napoli as Jurgen Klopp’s men look to beat the Italian side to secure their place in the last 16.
The Reds lost 2-0 to Napoli at the Stadio San Paolo in their group-stage opener back in September before securing three successive victories over RB Salzburg and Genk.
Liverpool FC have won 12 of their 13 Premier League fixtures so far this season, only dropping points in a 0-0 draw with Manchester United at Old Trafford in November.
Napoli, on the other hand, are winless in their last six games in all competitions to heap pressure on former Chelsea FC manager Carlo Ancelotti at the club.
However, Sky Sports pundit Nicholas is still confident that Napoli will hold Liverpool FC to a draw at Anfield on Wednesday night.
“This is another cracker,” Nicholas told Sky Sports.
“These two will go through, but Napoli do not lose many games. They are still unpredictable in terms of their defence. They are powerful but, no matter who the manager is, Napoli do like to get at you and take a risk or two.
“Liverpool are getting over the line at the moment, but it is taking its toll. Do you risk Mohamed Salah again or do you play him against Brighton on Saturday? I have a feeling Liverpool may tinker the team and if you said to both clubs that they would get a point, be content, and qualify at the end of it, they would be more than happy. Liverpool changes may affect the team.”
Liverpool FC have won eight of their 12 games against Italian opposition at Anfield, losing four times.
However, Klopp’s side have won their last seven group-stage fixtures at Anfield, scoring 24 goals.
Liverpool FC won the Champions League title last season thanks to a 2-0 victory over Tottenham Hotspur.
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