The Red Devils will be looking to pick up three points against the visitors after Manchester United lost 1-0 to Bournemouth on the south coast last weekend.
The 20-time English champions slumped to a fourth defeat of the Premier League season to leave Manchester United a worrying 10 points adrift of the top four.
Ole Gunnar Solskjaer’s side have only managed to win one of their last six Premier League games – a 3-1 victory at promoted side Norwich City last month.
Manchester United have only beaten Chelsea FC and Leicester City at Old Trafford this season, otherwise drawing twice and losing to Crystal Palace at home.
Brighton don’t have a great record on the road in the Premier League and the Seagulls haven’t won an away fixture since a 3-0 victory over Watford at Vicarage Road in August.
Former Manchester United striker Owen is backing the Red Devils to ease to a comfortable win against Brighton at Old Trafford on Sunday afternoon.
“Manchester United are struggling to keep a clean sheet on the road in the Premier League but they can surely keep the points when Brighton are the visitors to Old Trafford this weekend,” Owen told BetVictor.
“The Seagulls have won their last three home league games but have not won on the road since their opening day success at Vicarage Road and United will be grateful of being back on home soil this week after a run of four successive away games in three different competitions.”
Manchester United head into the game on the back of their 3-0 win over Partizan Belgrade in the Europa League on Thursday night.
The Red Devils have only finished in the top four on two occasions since Sir Alex Ferguson’s retirement in 2013.
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