Spurs will be looking to return to winning ways following a disappointing run of results in the Premier League.
Tottenham have only managed to win four of their 11 games in the Premier League so far this season.
The Lilywhites have lost three of their last six outings to leave Mauricio Pochettino’s side in the bottom half of the table.
Spurs squandered a lead on Merseyside for the second successive weekend after Everton held Tottenham to a 1-1 draw at Goodison Park.
Tottenham are in 13th place and four points above the relegation zone.
The Champions League has provided Tottenham with some respite following their 5-0 win over Red Star Belgrade last time out.
Pochettino’s men will need to beat Red Star Belgrade given Spurs are in second place and a point ahead of Wednesday night’s opponents.
Former Arsenal midfielder Nicholas is backing Tottenham to ease to a narrow 2-1 win against Red Star Belgrade.
“Red Star Belgrade put themselves in the shop window when they play at home, but they freeze away from home,” Nicholas told Sky Sports.
“Red Star will not be fooled by what they have to do, but they will have been embarrassed by what they went through in London. If Harry Kane is fit, does Christian Eriksen drop out? Dele Alli scoring against Everton forces the hand there, but where does Lucas Moura stand?
“Tottenham are only a point above Red Star. Bayern Munich will cruise through this group and it is about who finishes second. If they don’t go through, there will be major questions asked and a lot of players and staff will come under scrutiny.”
The Lilywhites picked up only two points on their travels in the 2018/19 Champions League group stage.
They’ve won only three of their 13 away group matches in the UEFA Champions League – and one of the last six.
MORE: Man United latest news
MORE: Arsenal latest news
MORE: Chelsea latest news
MORE: Liverpool latest news