The Red Devils will be desperate to return to winning ways on Sunday to keep their fading top-four hopes alive.
Manchester United were held to a 3-3 draw by promoted side Sheffield United at Bramall Lane last weekend.
The 20-time English champions missed out on the chance to secure back-to-back Premier League victories for the first time this season after conceding a 90th-minute equaliser at Bramall Lane.
Manchester United have their lowest points tally at this stage of the season since the 1988-89 season.
The Red Devils have paid the price for sloppy defending in recent months, failing to keep a clean sheet in their last 12 league games.
However, Aston Villa have only managed to beat Manchester United once in 40 meetings in the Premier League.
The promoted side have only collected three points on the road in the Premier League since their return to the top flight – a 5-1 victory at Norwich City.
Former Arsenal midfielder Nicholas is backing Manchester United to edge to a narrow 1-0 win over Aston Villa at Old Trafford.
Nicholas told Sky Sports: “Man Utd are shocking defensively. David de Gea is not mentioned anymore – he is not making mistakes but he is not saving shots, which is what he came synonymous for.
“He has won the Player of the Year award many times for them, and some of that was under Mourinho and even Louis van Gaal. Nobody mentions him as a top-level player any more,” Nicholas told Sky Sports.
“Ashley Young has been found out that he was never a left-back or right-back, so why give him a contract?
“Seriously, Man Utd where are you going? Brandon Williams and Mason Greenwood have been decent, but can they carry them along? Can Marcus Rashford do it? You cannot survive on 10 minutes of football.
“They don’t want change, they want to build. They understand the youth, it will not be the Class of ’92 because you will never get that again, but for now, the younger ones are good and helping.
“I do not know the philosophy for Man Utd but I think they will get over the line in this one. It is a needs-must kind of game.”
Manchester United started the Premier League weekend nine points adrift of fourth-placed Chelsea FC.
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